Pofut1 point-mutations that disrupt O-fucosyltransferase activity destabilize the protein and abolish Notch1 signaling during mouse somitogenesis.

The segmental pattern of the vertebrate body is established via JEWELRYRINGS the periodic formation of somites from the presomitic mesoderm (PSM).This periodical process is controlled by the cyclic and synchronized activation of Notch signaling in the PSM.Protein O-fucosyltransferase1 (Pofut1), which transfers O-fucose to the EGF domains of the Not

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Measles outbreak in a poorly vaccinated region in Cameroon: a case series study, public health challenges and recommendations

Measles is a highly contagious viral infection and still a leading cause of vaccine-preventable deaths in Africa; especially in unvaccinated populations.We reviewed the medical reports of the measles outbreak that occurred in Misaje, Facial Tissue in the North west region of Cameroon from 11/03/2015 to 14/05/2015.Six measles cases were recorded dur

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A Multistate Friction Model for the Compensation of the Asymmetric Hysteresis in the Mechanical Response of Pneumatic Artificial Muscles

These days, biomimetic and compliant actuators have been made available to the main applications of rehabilitation and assistive robotics.In this context, the interaction control of soft robots, mechatronic surgical instruments and robotic prostheses can be improved through the adoption of pneumatic artificial muscles (PAMs), a class of compliant a

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